Regulators of gene expression are thought to play an outsized role in disorders from cancers to heart disease. But how exactly do variations in gene regulation translate into a disease's biology?
Mar 28, 2024
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Researchers at the University of Toronto's Donnelly Center for Cellular and Biomolecular Research have found nearly one million new exons—stretches of DNA that are expressed in mature RNA—in the human genome.
Feb 9, 2024
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RIKEN geneticists have developed a tool that can quickly and accurately analyze variants in mobile genetic elements, commonly known as "jumping genes." This promises to shed light on the role such variants play in disease.
Oct 31, 2023
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Cancer research has long focused on targeting the genetic mutations that drive tumors. Many of these genetic changes affect genes that allow mutated cells to replicate out of control. While developing drugs to target these ...
Oct 16, 2023
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Genetically speaking, we are individuals different from each other because of slight variations in our DNA sequences—so-called genetic variants—some of which have dramatic effects we can see and comprehend, from the color ...
Sep 15, 2023
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Researchers at Baylor College of Medicine have linked specific variants or mutations of the gene myocardin-related transcription factor B (MRTFB) with a novel neurodevelopmental disorder.
May 9, 2023
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Rett syndrome is a rare, progressive neurodevelopmental disorder that typically affects girls, causing severe intellectual disability, loss of motor skills, and autism-like symptoms, and there is currently no cure. Rett syndrome ...
Jan 20, 2023
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In the largest genetic study of heart arrhythmia to date, researchers led by Kazuo Miyazawa and Kaoru Ito at the RIKEN Center for Integrative Medical Sciences (IMS) in Japan report the discovery of several genes and individual ...
Jan 19, 2023
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Danielle Dick, a professor of psychiatry at Robert Wood Johnson Medical School who leads the Rutgers Addiction Research Center, has spent decades hunting genes that contribute to drug and alcohol addiction.
Nov 2, 2022
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The research group led by immunologists Vigo Heissmeyer and Taku Ito-Kureha of LMU and Helmholtz Munich has revealed the essential function of m6A modifications in T cells.
Jul 27, 2022
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