Morphine and other opioids are vital to treat severe and chronic pain. However, they have two problems—prolonged use creates morphine tolerance, where ever-increasing doses are needed for the same pain relief, and paradoxically, ...
Apr 9, 2024
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Scripps Research scientists have found that LY2444296—a compound that selectively blocks the kappa opioid receptor (KOP)—may reduce drinking in cases of alcohol dependence in animal studies. The findings, which were published ...
Mar 29, 2024
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Researchers at Karolinska Institutet, in collaboration with JLP Health and others, have identified how the tick-borne Crimean-Congo hemorrhagic fever virus enters our cells. The results are published in Nature Microbiology ...
Mar 28, 2024
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Research from the University of Virginia School of Medicine could pave the way for new treatments to manage migraines and chronic pain in women, improving their quality of life. The work is published in The Journal of Pain.
Feb 21, 2024
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The herbal substance kratom, derived from the leaves of a Southeast Asian tree, is used by nearly 2 million people in the United States annually. It can be easily purchased at gas stations and convenience stores, smoke shops ...
Feb 21, 2024
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A new approach to treating neuropathic pain is making a key step forward thanks to researchers at The University of Texas at Austin.
Jan 30, 2024
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People often experience headaches and body pain after a lack of sleep, but the mechanisms behind this phenomenon are unclear. A new study led by investigators at Massachusetts General Hospital (MGH), a founding member of ...
Oct 25, 2023
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Researchers at Queen Mary University of London's Precision Healthcare Research Institute (PHURI) and the Berlin Institute of Health (BIH) at Charité—Universitätsmedizin Berlin have identified the genetic causes of Raynaud's ...
Aug 18, 2023
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Cisplatin is a potent chemotherapeutic agent used to treat various cancers, including cervical cancer. But the continued use of cisplatin can lead to the development of cisplatin resistance and other side effects, like chemotherapy-induced ...
Jul 20, 2023
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Opioids such as morphine are the gold standard for treating cancer-induced bone pain, but new University of Arizona Health Sciences research published in the journal Pain uncovers a mechanism by which chronic morphine use ...
Jul 6, 2023
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