Genetics

Study links gene mutation to learning deficits in 'Clueless' mice

A single mutation in a gene, Kcnc3, which encodes a potassium channel in neurons, causes learning deficits in mice, UT Southwestern researchers report in a new study in PNAS. The novel mutation decreases the activity of neurons ...

Medications

Study sheds new light on a promising antidepressant

Ketamine, a well-known anesthetic used in smaller doses as a party drug, was hailed as a "new hope for depression" in a Time magazine cover story in 2017. Two years later, the arrival of the first ketamine-based antidepressant—the ...

Genetics

Potassium channel dysfunction in genetic epilepsy

Northwestern Medicine scientists have discovered functional links between dozens of potassium channel gene variants and neonatal epilepsy, according to a study published in JCI Insight.

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