A highly aggressive common form of leukemia which is activated by mutations in signaling molecules is maintained by a web of regulatory proteins downstream of these signals.
Dec 20, 2023
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21
Scientists at St. Jude Children's Research Hospital described the gene regulatory networks contributing to differences between subtypes of the most common childhood cancer, acute lymphoblastic leukemia (ALL). The work examined ...
Nov 20, 2023
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57
The spinal cord links and allows communication between the brain and peripheral organs, coordinating the movement and the sensation of the body. The spinal cord formation begins around embryonic day 9 (e9) in mice. During ...
Dec 22, 2022
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87
National Eye Institute researchers mapped the organization of human retinal cell chromatin, the fibers that package 3 billion nucleotide-long DNA molecules into compact structures that fit into chromosomes within each cell's ...
Oct 7, 2022
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Mild, persistent inflammation in tissue is considered one of the biological hallmarks of the aging process in humans—and at the same time is a risk factor for diseases such as Alzheimer's or cancer. Prof. Francesco Neri ...
Sep 22, 2022
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Using new technologies to study thousands of genes simultaneously within immune cells, researchers at Gladstone Institutes, UC San Francisco (UCSF), and Stanford School of Medicine have created the most detailed map yet of ...
Jul 11, 2022
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Up to 60 percent of the risk associated with coronary arteriosclerosis may be explained by changes in the activity of hundreds of genes working together in networks across several organs in the body. Moreover, fat processing ...
Jan 12, 2022
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48
Activating the immune system to battle infections or cancers depends on more than detecting the threat. The immune system must also detect whether its cells have sufficient nutrients to fuel the immune response.
Nov 19, 2021
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64
Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer with a high fatality rate. Currently, chemotherapy is the major treatment option, but the clinical result is unsatisfactory. A research team led ...
Apr 15, 2021
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11
Healthy cells and cells with type 2 diabetes use completely different pathways to manage blood sugar levels, according to results from a study in mice. Researchers used a trans-omic approach, combining data from genes (transcriptomics) ...
Dec 1, 2020
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