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Immunology news
Genetics
Biomolecular atlas for bone marrow offers unprecedented window into blood production
Researchers at Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have revealed a powerful new bone marrow atlas that will offer the public a first-of-its-kind ...
8 hours ago
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Oncology & Cancer
Study uncovers at least one cause of roadblocks to cancer immunotherapy
T cells—the body's foot soldiers against invaders, ranging from everyday infections to cancers—are integral to many successful immunotherapies. However, a frustrating factor is that immunotherapies do not always work.
11 hours ago
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Vagus nerve activation of the spleen shows promise to treat infections
One of the main roles of the spleen is to help the body's immune system fight infections. The spleen does this through producing and regulating antibodies—antibody production is negatively affected in various conditions, ...
12 hours ago
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Study provides a blueprint of tumor-infiltrating B cells with therapeutic implications
In a study published in Science on May 3, researchers unveiled two responding patterns of tumor-infiltrating B cells with therapeutic implications.
14 hours ago
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Researchers find B cells drive responses of other immune cells, can be modified to prevent multiple sclerosis symptoms
B cells can control responses of myeloid cells through the release of particular cytokines (small proteins that control the growth and activity of cells in the immune system), disproving the previous consensus that T cells ...
14 hours ago
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Researchers generate direct measurement of interaction between immune cells and cancer cells from a patient's biopsy
Researchers at Bar-Ilan University have unveiled a technology that promises to improve cancer treatment decisions based on a patient's biopsy. The pioneering biological research and development measures changes in immune ...
7 hours ago
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Scientists discover new immunosuppressive mechanism in brain cancer
The Wistar Institute assistant professor Filippo Veglia, Ph.D., and team, have discovered a key mechanism of how glioblastoma—a serious and often fatal brain cancer—suppresses the immune system so that the tumor can grow ...
May 3, 2024
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Newly discovered mechanism of T-cell control can interfere with cancer immunotherapies
Activated T cells that carry a certain marker protein on their surface are controlled by natural killer (NK) cells, another cell type of the immune system. In this way, the body presumably curbs destructive immune reactions.
May 3, 2024
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Pan-cancer analysis uncovers a new class of promising CAR T–cell immunotherapy targets
Targeting anti-cancer therapy to affect cancer cells but not healthy cells is challenging. For chimeric antigen receptor (CAR) T–cell immunotherapy, where a patient's own immune cells are re-engineered to attack cancer ...
May 3, 2024
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Lymphocytes recruit the immune system to fight most aggressive breast cancer, study confirms
Researchers at the UAB and the Hospital del Mar Research Institute have confirmed that patients with the presence of NK lymphocytes around tumors have a better response to treatment. This confirms the feasibility of using ...
May 3, 2024
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New approach for developing cancer vaccines could make immunotherapies more effective in acute myeloid leukemia
Acute myeloid leukemia (AML) is a type of blood cancer that forms in the soft marrow of the bones, typically attacking cells that would otherwise form the key component of the body's immunodefense system, white blood cells.
May 3, 2024
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Drug targeting RNA modifications shows promise for treating neuroblastoma
Neuroblastoma is a common pediatric cancer that originates in developing nerve cells outside the brain. While increasingly intensive treatments have improved the survival of patients with high-risk neuroblastoma, currently ...
May 3, 2024
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Researchers discover how immune B cells hunt down cancer around the body
Scientists have discovered the key features of immune B cells that make them successful at targeting tumors—including when cancer has spread to a different part of the body.
May 2, 2024
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Controlled human infection study paves the way to improving vaccines and therapeutics development
A first-of-its-kind study led by the University of Oxford has successfully investigated human immunity against COVID-19 in people who already have antibodies against it. The results suggest that previous infection, together ...
May 2, 2024
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Turning a tumor's 'shield' into a weapon against itself
Tumor cells are "cunning," according to Peter Yingxiao Wang. They have a nefarious way of evading the human immune responses that fight back against these cancerous invaders. Tumor cells express programmed death-ligand 1 ...
May 2, 2024
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Gene signatures from tissue-resident T cells as a predictive tool for melanoma patients
An extensive analytical study conducted at the Terasaki Institute for Biomedical Innovation (TIBI) has revealed an association between favorable survival outcomes for melanoma patients and the presence of higher populations ...
May 2, 2024
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Study reveals hidden diversity of innate immune cells
Findings from a new study, led by researchers at Dartmouth's Geisel School of Medicine and published in Nature Immunology, have uncovered key functional differences in macrophages—a type of white blood cell that plays a ...
May 2, 2024
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Activation of innate immunity: Important piece of the puzzle identified
LMU researchers have deciphered the complex interplay of various enzymes around the innate immune receptor toll-like receptor 7 (TLR7), which plays an important role in defending our bodies against viruses.
May 2, 2024
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Skin patch improves treatment for pediatric milk allergies
Daily immunotherapy delivered via a dermal patch reduced the risk of reactions, including anaphylaxis, in children with an immunoglobulin E (IgE)–mediated cow's milk allergy, according to a recent clinical trial published ...
May 2, 2024
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Molecular testing: Pioneering precision medicine for colorectal cancer
A new perspective paper explores the current state and future directions of precision medicine in colorectal cancer (CRC). It outlines advancements in molecular testing and their implications for targeted and immunological ...
May 2, 2024
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