Medical research

Elimination of senescent cells improves lung function in mice

Most cells can divide only a limited number of times and eventually undergo permanent cell cycle arrest, a state known as cellular senescence. Cellular senescence is mediated by activation of specific cellular signaling pathways ...

Neuroscience

Controller in the cell

Quality control is important – this is not only applicable to industrial production but also true for all life processes. However, whereas an enterprise can start a large-scale recall in case of any doubt, defects in the ...

Oncology & Cancer

Genetic master controls expose cancers' Achilles' heel

In a surprising finding that helps explain fundamental behaviors of normal and diseased cells, Whitehead Institute scientists have discovered a set of powerful gene regulators dubbed "super-enhancers" that control cell state ...

Medical research

Bioelectric signals can be used to detect early cancer

Biologists at Tufts University School of Arts and Sciences have discovered a bioelectric signal that can identify cells that are likely to develop into tumors. The researchers also found that they could lower the incidence ...

Genetics

Human genome far more active than thought

The GENCODE Consortium expects the human genome has twice as many genes than previously thought, many of which might have a role in cellular control and could be important in human disease. This remarkable discovery comes ...

Medical research

Giant raft of data to help us understand disease

Scientists at the Novo Nordisk Foundation Center for Protein Research at the University of Copenhagen have used a new method to assemble a massive catalogue of data on proteins. This gives them unprecedented insight into ...

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