The molecular switches regulating human cell growth do a great job of replacing cells that die during the course of a lifetime. But when they misfire, life-threatening cancers can occur. Research led by scientists at The ...
Aug 24, 2015
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Researchers at University of California, San Diego School of Medicine have discovered a self-regulating loop in the Hippo pathway, a signaling channel garnering increased attention from cancer researchers due to its role ...
Jun 26, 2015
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MEHD7945A, a dual-action antibody that targets two members of the epidermal growth factor receptor (EGFR) family, was found to be safe and showed clinical activity in some patients with locally advanced or metastatic refractory ...
Jun 2, 2015
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Zinc deficiency - long associated with numerous diseases, e.g. autism, lung cancer, prostate cancer, and ovarian cancers - can lead to activation of the Hedgehog signaling pathway, a biomolecular pathway that plays essential ...
Apr 16, 2015
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Mutations in the KRAS gene have long been known to cause cancer, and about one third of solid tumors have KRAS mutations or mutations in the KRAS pathway. KRAS promotes cancer formation not only by driving cell growth and ...
Nov 26, 2014
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Healthy cells reduce their growth when there is a lack of oxygen (hypoxia). This makes it even more surprising that hypoxia is a characteristic feature of malignant tumours. In two publications in the current edition of the ...
Nov 25, 2014
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A trawl through a library of more than 50,000 'small molecules' has identified a potential candidate to inhibit the spread of cancer cells throughout the body. Reported today in the journal Nature Communications, the molecule ...
Nov 12, 2014
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Researchers at the Bellvitge Biomedical Research Institute (IDIBELL) and the University of Barcelona have discovered the interaction between HERC2 proteins with another protein called p53 that is inactivated in more than ...
Jul 21, 2014
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(Medical Xpress)—The hallmark of cancer is uncontrolled cell growth directed by a cell cycle engine gone into overdrive. The centrepiece of this engine is the enzyme Cdc2 kinase. While Cdc2 kinase is tightly regulated in ...
Jun 11, 2014
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Researchers at the University of California, San Diego School of Medicine have identified a therapeutic target for treating the most common form of eye cancer in adults. They have also, in experiments with mice, been able ...
May 29, 2014
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